Effects of green tea epigallocatechin-3-gallate (EGCG) on the formation of mineralized bone nodules by human osteoblast-like cells.
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Effects of green tea epigallocatechin-3-gallate (EGCG) on the formation of mineralized bone nodules by human osteoblast-like cells.

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Published .
Written in English


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Consumption of green tea, a rich source of epigallocatechin-3-gallate (EGCG), is associated with increased bone mineral density in humans. The present study demonstrates the effects of EGCG on the formation of mineralized bone nodules by SaOS-2 human osteoblast-like cells. EGCG, at concentrations of 1-5 muM, caused a dose-dependent increase in the number and area of mineralized bone nodules. EGCG also increased alkaline phosphatase (ALP) activity, an early marker of osteoblastic differentiation. This observation was accompanied by an initial increase in cell proliferation followed by a decline in proliferation at the end of the culture period. After 48 hours of treatment, EGCG decreased protein levels of Runx2, a transcription factor that regulates osteoblast maturation by enhancing early-stage differentiation and inhibiting late-stage differentiation. The observed effects of EGCG on bone formation by human osteoblast-like cells suggest that EGCG may have beneficial effects on bone health.

The Physical Object
Pagination93 leaves.
Number of Pages93
ID Numbers
Open LibraryOL19217580M
ISBN 100494074515

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Recently, one clinical case with cardiac involvement, as well as a compelling evidence of green tea polyphenol, epigallocatechingallate (EGCG), inducing the formation of benign aggregation products that do not polymerize into fibrils were published. This is a report of the cardiac effects of green tea Cited by: Green tea polyphenol epigallocatechingallate improves the antioxidant capacity of eggs Jianping Wang, † a Ru Jia, † a Pietro Celi, bc Xuemei Ding, a Shiping Bai, a Qiufeng Zeng, a Xiangbing Mao, a Shengyu Xu Cited by: 2.   (-)-Epigallocatechingallate (EGCG) is the major tea catechin and accounts for 50–80% of the total catechin in green tea. (-)-Epigallocatechingallate has antioxidant, anti Cited by: The present study evaluated the effect of epigallocatechingallate (EGCG), the most abundant catechin in green tea, on irradiation-induced pulmonary fibrosis and elucidated its mechanism of action. A rat model of irradiation-induced pulmonary fibrosis .

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